cilnidipine + metoprolol succinate

Dinmet-XL is a fixed-dose combination pharmaceutical product containing **cilnidipine**, a dual L/N-type calcium channel blocker, and **metoprolol succinate**, a cardioselective beta-1 adrenergic antagonist. The "XL" designation indicates an extended-release formulation, typically applied to the metoprolol component to provide sustained blood pressure control over 24 hours. Cilnidipine acts by inhibiting L-type calcium channels in vascular smooth muscle to induce vasodilation and N-type calcium channels in sympathetic nerve terminals to suppress norepinephrine release, thereby reducing reflex tachycardia. Metoprolol succinate reduces cardiac output and heart rate by selectively blocking beta-1 receptors in the heart. This combination is primarily indicated for the management of hypertension, particularly in patients where monotherapy is insufficient or where the dual mechanism of sympathetic suppression and vasodilation is clinically preferred.

Brand names

Dinmet-XLDinmet-XL 25Dinmet-XL25Dinmet-XL-25Dinmet-XL 50Dinmet-XL50Dinmet-XL-50Dinmet-XL AM 5/50

Other names

cilnidipine and metoprolol succinate extended-releasecilnidipine/metoprolol succinate