cimicifuga racemosa rhizome extract

Remifemin Mono is an herbal medicinal product developed by Schaper & Brümmer for the treatment of menopausal symptoms, including hot flashes, night sweats, and sleep disturbances. The active ingredient is a standardized isopropanolic aqueous extract of the rhizome of *Cimicifuga racemosa* (black cohosh), often referred to in clinical literature as iCR. Unlike traditional hormone replacement therapy (HRT), Remifemin Mono is a non-hormonal treatment option that does not exhibit systemic estrogenic effects on the uterus or breast tissue. Its therapeutic efficacy is attributed to the modulation of various neurotransmitter systems, particularly the serotonergic, dopaminergic, and opioid pathways, which play key roles in thermoregulation and mood stabilization during the menopausal transition. It is widely marketed as an over-the-counter (OTC) pharmaceutical in Europe, particularly in Germany, where it is regulated as a medicinal product.

Brand names

Remifemin MonoRemifemin

Other names

Remifemin Monocimicifuga racemosa rhizome extractiCRblack cohosh extractisopropanolic Cimicifuga racemosa extract