Drug intelligence / Profile preview

cimicoxib

Development stage
Phase 2
Lead developer
Palau Pharma
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Cimicoxib is a nonsteroidal anti-inflammatory drug (NSAID) and an imidazole derivative that acts as a selective cyclooxygenase 2 (COX-2) inhibitor. It is primarily used in veterinary medicine, especially for dogs, to control pain and inflammation associated with osteoarthritis and for the management of peri-operative pain. By selectively inhibiting COX-2, cimicoxib reduces the production of prostaglandins involved in inflammation and pain signaling. Cimicoxib was also investigated as a potential treatment for depression and schizophrenia due to its novel mechanism but has not advanced beyond early clinical development in humans[1][3][8].

Brand names
Cimalgex
Other names
4-[4-Chloro-5-(3-fluoro-4-methoxyphenyl)-1H-imidazol-1-yl]benzenesulfonamide
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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