Drug intelligence / Profile preview

Cinazin-D

Development stage
Unknown
Lead developer
Getz Pharma
Modality
Small Molecules
Administration
Oral
01

Overview

Cinazin-D is a fixed-dose combination tablet containing cinnarizine (20 mg) and dimenhydrinate (40 mg), developed and marketed by Getz Pharma. It is indicated for the short-term, symptomatic treatment of vertigo of various causes, dizziness, motion sickness, and associated nausea and vomiting. Cinnarizine acts as a selective calcium channel blocker and antihistamine, primarily targeting the peripheral vestibular system to improve inner ear microcirculation and reduce vestibular overstimulation. Dimenhydrinate acts centrally as an antihistamine and anticholinergic agent, targeting the vestibular nuclei in the brainstem to suppress nausea and vomiting. Together, these two active ingredients provide a synergistic dual-action effect that is more effective than either monotherapy alone.

Brand names
Cinazin-D
Other names
cinnarizine + dimenhydrinate
02

Targets

HRH1 (Histamine H1 Receptor)mAChR (Muscarinic acetylcholine receptors)CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)CaV3 (Caveolin-3)

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