cinchocaine

Cinchocaine is a potent amide-type local anesthetic primarily used for surface (topical) and spinal anesthesia. It is among the most potent and toxic of the long-acting local anesthetics. Its mechanism of action involves blocking both the initiation and conduction of nerve impulses by decreasing neuronal membrane permeability to sodium ions through inhibition of sodium channels. This stabilizes the membrane and inhibits depolarization, resulting in failure to propagate action potentials and subsequent conduction blockade[1][2][7]. Cinchocaine is commonly found as an active ingredient in topical hemorrhoid creams (such as Proctosedyl) for relief from pain and itching due to minor burns, cuts, hemorrhoids, sunburns, insect bites, or other skin irritations[4]. It is also used in veterinary medicine as part of euthanasia solutions for large animals[1][4]. Due to its high neurotoxicity risk when administered parenterally (e.g., spinal anesthesia), its use has been restricted or withdrawn for some indications.

Brand names

CincainNupercainalNupercaineSovcaineProctosedyl OintmentProctolFaktu

Other names

cinchocaine hydrochloride