cinnamaldehyde (Aalborg University)

Cinnamaldehyde is a naturally occurring small molecule and the primary constituent of cinnamon bark oil. It is widely recognized in pharmacology as a potent and selective agonist of the **Transient Receptor Potential Ankyrin 1 (TRPA1)** ion channel. In clinical research settings, such as those conducted by Aalborg University, cinnamaldehyde is utilized as an experimental pharmacological probe rather than a therapeutic agent. It is applied topically or intradermally to healthy volunteers to induce TRPA1-mediated sensory responses, including pain and non-histaminergic itch. This application serves to characterize sensory pathways and evaluate the efficacy of surrogate models, such as BAM8-22, in the study of chronic itch mechanisms.

Other names

(E)-3-phenylprop-2-enalcinnamic aldehydetrans-cinnamaldehyde