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cinnamon leaf extract
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Cinnamon leaf extract is a botanical derivative, notably from the *Cinnamomum osmophloeum* species native to Taiwan, containing a variety of bioactive secondary metabolites such as cinnamaldehyde, cinnamic acid, phenolic acids, and flavonoids. It is recognized for its multi-functional pharmacological profile, exhibiting anti-inflammatory, neuroprotective, hypoglycemic, and hypolipidemic properties. In neurodegenerative research, particularly for Parkinson's disease, the extract and its nanoemulsion formulations have shown potential in protecting dopaminergic neurons and reducing oxidative stress in animal models. Its therapeutic effects are attributed to the synergistic action of its constituent phenylpropanoids and polyphenols.
- Other names
- Cinnamomum osmophloeum leaf extractC. osmophloeum leaf extractTaiwan cinnamon leaf extract
02
Targets
DHFR (Dihydrofolate reductase)NF-κBVEGFR2 (Vascular endothelial growth factor receptor 2)ACE2 (Angiotensin-converting enzyme 2)PIM1 (Proviral integration site for moloney murine leukemia virus kinase 1)HIF1A (Hypoxia-inducible factor 1-alpha)MAPK14 (p38 mitogen-activated protein kinase alpha)FOS (Activator Protein 1)
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