Drug intelligence / Profile preview

Cinnulin PF

Development stage
Unknown
Lead developer
Integrity Neutraceuticals
Modality
Small Molecules
Administration
Oral
01

Overview

Cinnulin PF is a patented water-soluble cinnamon extract derived from cinnamon bark, specifically formulated to concentrate the beneficial components of cinnamon while filtering out potential toxins. Based on the search results, I can provide comprehensive information about this dietary supplement. ## Composition and Formulation Cinnulin PF is standardized to contain 3% Type-A polymers, which are double-linked procyanidin flavonoids[3][9]. It's produced using a proprietary extraction process called Controlled Polymer Purification Technology (CPPT) that isolates the biologically active compounds from potential toxins found in whole cinnamon[9]. The extract is derived from the bark of cinnamon trees, specifically Cinnamomum cassia and/or Cinnamomum burmanni[4][5]. ## Health Benefits Research suggests that Cinnulin PF offers several potential health benefits: **Blood Sugar Management**: Clinical studies have shown that Cinnulin PF can support healthy blood glucose levels. In one study, 83% of participants given Cinnulin PF experienced a decrease in fasting blood sugar (approximately 8% drop) compared to only 33% in the placebo group[6]. **Cardiovascular Support**: Cinnulin PF has been shown to support healthy blood pressure. A 12-week study demonstrated that subjects taking Cinnulin PF decreased their systolic blood pressure by 3.8% compared to the placebo group[3]. **Body Composition**: Research indicates that Cinnulin PF may help improve body composition, with studies showing statistically significant improvements in lean body mass[3][5]. **Antioxidant Properties**: Cinnulin PF has demonstrated antioxidant effects, which may contribute to its overall health benefits[6][8]. ## Mechanism of Action Cinnulin PF appears to work through several mechanisms: - Enhancing insulin sensitivity by increasing glucose uptake in skeletal muscle[8] - Stimulating autophosphorylation of the insulin receptor[5] - Affecting glucose transport mechanisms[5] - Influencing phosphatidylinositol 3-kinase activity[5] - Modulating protein tyrosine phosphatase[5] - Improving endothelial cell function and glucose uptake[5] - Promoting cell migration at lower concentrations (20 μg/mL)[8] ## Safety Profile Cinnulin PF is generally considered safe for daily use. Unlike whole cinnamon or other cinnamon extracts, it contains virtually no cinnamaldehyde or other toxins that can be found in whole cinnamon[6]. In clinical studies, no adverse events were reported, and compliance was high (>97%)[3]. ## Dosage and Administration The typical recommended dosage varies by product: - 250mg daily, which can be taken as two 125mg capsules before meals[2][6] - Some products suggest taking one 150mg capsule three times per day with water before meals[4] The extract is available in various forms including capsules, tablets, and powder formulations[5]. Cinnulin PF represents an example of how traditional ingredients like cinnamon can be refined using modern extraction techniques to create standardized supplements with specific health applications, particularly for metabolic health support.

Brand names
Cinnulin PF
Other names
cinnamon extractwater-soluble cinnamon extractaqueous extract of cinnamoncinnamon extract-Rogerio A. Lobo-polycystic ovary syndrome
02

Targets

PI3K (Phosphoinositide-3-kinase regulatory subunit 6)SLC2A4 (Solute carrier family 2 facilitated glucose transporter member 4)

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