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cinobufacini (Beijing University of Chinese Medicine East Hospital)
- Development stage
- Unknown
- Lead developer
- Beijing University of Chinese Medicine East Hospital
- Modality
- Small Molecules
- Administration
- Intraperitoneal
01
Overview
Cinobufacini (also known as Huachansu) is a traditional Chinese medicine injection extracted from the skins and parotid venom glands of the toad *Bufo bufo gargarizans*. Its active ingredients are primarily bufadienolides, which are cardiac glycosides. Cinobufacini has demonstrated anti-cancer properties by inducing apoptosis, suppressing cell proliferation, and inhibiting angiogenesis. It is being developed by Dongfang Hospital of Beijing University of Chinese Medicine in a Phase 1 clinical trial for the intraperitoneal treatment of malignant ascites in patients with digestive system cancer. This specific trial evaluates a local administration route to control ascites, whereas the drug is also available in other formulations for treating various malignant neoplasms.
- Other names
- HuachansuCinobufacini injection
02
Targets
ATP1A (Sodium/potassium-transporting ATPase)
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