ciprofol + alfentanil

ciprofol + alfentanil is a pharmacological combination used for procedural sedation and analgesia, particularly in the context of gastrointestinal endoscopies such as gastroscopy. Ciprofol (HSK3486) is a novel, short-acting intravenous anesthetic and a 2,6-disubstituted phenol derivative that functions as a potent agonist of the Gamma-aminobutyric acid type A (GABA_A) receptor. It was developed by Haisco Pharmaceutical Group to offer a similar clinical profile to propofol but with improved potency and a potentially better safety profile regarding injection pain and respiratory depression. Alfentanil is a potent, rapid-onset synthetic opioid that acts as a selective agonist of the mu-type opioid receptor, providing the necessary analgesia that hypnotics like ciprofol lack. When administered together, these agents provide a rapid onset of action, stable hemodynamics, and quick recovery times, making the combination suitable for brief diagnostic and therapeutic procedures.

Brand names

XuanningRapifen

Other names

ciprofol/alfentanilHSK3486 plus alfentanilHSK-3486 plus alfentanilHSK 3486 plus alfentanil