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circCDR1-AS-shRNA

Development stage: Preclinical
Modality: Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics

Overview

circCDR1-AS-shRNA is an experimental short hairpin RNA (shRNA) construct designed to silence the expression of the circular RNA circCDR1-AS (also known as CDR1as or CiRS-7). In the context of castration-resistant prostate cancer (CRPC), circCDR1-AS is a key component of an androgen receptor (AR)-mediated signaling axis (AR/CDR1/circCDR1-AS/miR-1290/BMP4) that promotes prostate cancer stem cell (CSC) traits and resistance to the antiandrogen enzalutamide. By knocking down circCDR1-AS, this therapy aims to disrupt this signaling pathway, thereby restoring enzalutamide sensitivity and inhibiting tumor progression. Preclinical studies in CWR22Rv1 xenograft mouse models have demonstrated its potential as a therapeutic strategy for advanced prostate cancer.

Other names: shRNA targeting circCDR1-AScircCDR1-AS short hairpin RNAcircCDR-1-AS short hairpin RNAcircCDR 1-AS short hairpin RNAshRNA-circCDR1-ASshRNA-circCDR-1-ASshRNA-circCDR 1-AS

Targets

CDR1-AS (Cerebellar degeneration-related protein 1 antisense RNA)

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