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Circle Pharma Cyclin E inhibitor
- Development stage
- Preclinical
- Lead developer
- Circle Pharma
- Modality
- Peptides, Small Molecules
- Administration
- Oral
01
Overview
Circle Pharma's Cyclin E program is a research-stage drug discovery effort focused on developing oral macrocycles that target Cyclin E. Utilizing the company's proprietary MXMO™ platform, these macrocycles are designed to disrupt the protein-to-protein interaction (PPI) between the cyclin's hydrophobic patch and the RxL motif of its substrate proteins. Cyclin E is frequently upregulated in various malignancies, including uterine and ovarian cancers, and its overexpression is a recognized mechanism of resistance to CDK4/6 inhibitors. By inhibiting Cyclin E-mediated signaling through this non-catalytic site disruption, the program aims to address unmet needs in solid tumors where Cyclin E drives aberrant cell cycle progression and therapeutic resistance.
- Other names
- Cyclin E research-stage targetCyclin E RxL inhibitorCircle Pharma Cyclin E program
02
Targets
CCNB1 (Cyclin B1)CCNE1 (Cyclin E1)CCNA2 (Cyclin A2)
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