Drug intelligence / Profile preview

circSLCO1B7 siRNA

Development stage: Preclinical
Modality: Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics

Overview

circSLCO1B7 siRNA is an experimental small interfering RNA (siRNA) designed to silence the expression of the circular RNA circSLCO1B7. In hepatocellular carcinoma (HCC), circSLCO1B7 has been identified as a tumor suppressor that is frequently downregulated in malignant tissues. It functions as a competitive endogenous RNA (ceRNA) by sponging miR-556-3p, which in turn upregulates the expression of the downstream target gene DAB2IP, thereby inhibiting the epithelial-mesenchymal transition (EMT) and tumor metastasis. The siRNA is used in preclinical research to demonstrate that the loss of circSLCO1B7 promotes cell growth, migration, and invasion, validating the circRNA as a potential therapeutic target for HCC.

Other names: si-circSLCO1B7si-circSLCO-1B7si-circSLCO 1B7

Targets

circSLCO1B7 (circular RNA SLCO1B7)

Beyond the preview

Go deeper on circSLCO1B7 siRNA.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on circSLCO1B7 siRNA.

Explore the full profile