cirsium japonicum extract

**Cirsium japonicum extract** is derived from the medicinal plant Cirsium japonicum (Asteraceae) and contains a variety of bioactive polyphenols and flavonoids, such as cirsimaritin, chlorogenic acid, luteolin, apigenin, linarin, pectolinarin, and acacetin[1][2][5][6]. It has demonstrated *antioxidant*, *anti-inflammatory*, *antidiabetic*, *anticancer*, *neuroprotective*, and *hepatoprotective* activities in preclinical studies[1][2][3][4][5][6][7]. The mechanism of action is mainly through modulation of inflammatory pathways (e.g., inhibition of cyclooxygenase-2 and inducible nitric oxide synthase), positive modulation of GABAA receptor, activation of AMP-activated protein kinase (AMPK) signaling, α-glucosidase inhibition, and induction of ferroptosis in cancer cells[1][2][4][5][6][7]. It is being investigated for its potential in treating metabolic disorders (such as fatty liver disease), diabetes, neurodegenerative conditions, and as an adjunct in cancer therapy[2][3][4][6][7].

Other names

CJEcirsium japonicum extractCJ extractHerba Cirsii extract