Drug intelligence / Profile preview

cirsium oligophyllum extract

Development stage
Preclinical
Lead developer
Kao
Administration
Oral, Topical
01

Overview

Cirsium oligophyllum extract is a botanical preparation derived from the aerial and/or whole parts of the thistle species *Cirsium oligophyllum*, native to East Asia and used traditionally in Chinese, Japanese, and Korean medicine. The extract contains bioactive compounds such as flavonoids, saponins, and polyphenols, and has been described in traditional uses for supporting blood circulation, reducing inflammation, promoting liver health, treating bleeding disorders, and wound healing[3][1]. Scientific studies have suggested that the extract promotes lipolysis (fat breakdown) via β adrenergic receptor activation and upregulation of uncoupling proteins (notably UCP1 and UCP3), contributing to reduced body fat and potential utility in managing obesity. These effects have been demonstrated primarily in animal models, with no robust clinical trials in humans to date[2][4][5]. Other proposed activities include antioxidant, anti-inflammatory, antimicrobial, and potential agricultural benefits.

Other names
cirsium oligophyllum whole plant extractcirsium oligophyllum decoctioncirsium oligophyllum tinctureCE
02

Targets

UCP3 (Mitochondrial uncoupling protein 3)

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