Drug intelligence / Profile preview

cisplatin + cyclophosphamide + docetaxel + epirubicin + gemcitabine

Development stage
Unknown
Lead developer
Eli Lilly
Modality
Small Molecules
Administration
Intravenous, Oral
01

Overview

This is a combination chemotherapy regimen consisting of five anticancer drugs: cisplatin, cyclophosphamide, docetaxel, epirubicin, and gemcitabine. Each component has different mechanisms of action: - Cisplatin is a platinum-based agent that crosslinks DNA, interfering with cell division - Cyclophosphamide is an alkylating agent that damages DNA and prevents cancer cell replication - Docetaxel is a taxane that disrupts microtubule function during cell division - Epirubicin is an anthracycline that intercalates DNA and inhibits topoisomerase II - Gemcitabine is a nucleoside analog that interferes with DNA synthesis This multi-agent combination likely targets different cellular mechanisms to enhance anticancer effects while potentially reducing resistance development.

02

Targets

DNA polymerase familyRNR (Ribonucleotide reductase)TOP2A (DNA topoisomerase II)DNATUBB (Tubulin (alpha and beta subunits))

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