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cisplatin + cyclophosphamide + epirubicin + etoposide + lomustine + methotrexate
- Development stage
- Preclinical
- Lead developer
- Michigan State University
- Modality
- Small Molecules
- Administration
- Intravenous, Oral, Intrathecal
01
Overview
A multi-agent chemotherapy combination consisting of cisplatin, cyclophosphamide, epirubicin, etoposide, lomustine, and methotrexate. This combination includes alkylating agents (cyclophosphamide, lomustine), platinum compounds (cisplatin), anthracyclines (epirubicin), topoisomerase inhibitors (etoposide), and antimetabolites (methotrexate), potentially providing broad-spectrum cytotoxic activity against cancer cells through multiple mechanisms.
- Other names
- CCNU + cisplatin + cyclophosphamide + epirubicin + etoposide + methotrexate
02
Targets
TOP2A (DNA topoisomerase II)DNADHFR (Dihydrofolate reductase)
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