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cisplatin + doxorubicin + fluorouracil + methotrexate + vincristine
- Development stage
- Unknown
- Lead developer
- Michigan State University
- Modality
- Small Molecules
- Administration
- Intravenous, Intrathecal
01
Overview
A combination chemotherapy regimen consisting of five cytotoxic agents: cisplatin (a platinum compound that crosslinks DNA), doxorubicin (an anthracycline that intercalates DNA and inhibits topoisomerase II), fluorouracil (an antimetabolite that inhibits thymidylate synthase), methotrexate (an antifolate that inhibits dihydrofolate reductase), and vincristine (a vinca alkaloid that binds to tubulin and disrupts microtubule formation). This multi-agent regimen would likely be used for aggressive or advanced cancers requiring multiple mechanisms of action.
02
Targets
TS (Thymidylate synthase)TOP2A (DNA topoisomerase II)DHFR (Dihydrofolate reductase)DNATUBB (Tubulin (alpha and beta subunits))
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