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cisplatin + doxorubicin + folinic acid + methotrexate + vinblastine
- Development stage
- Unknown
- Lead developer
- Michigan State University
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
A combination chemotherapy regimen consisting of five anticancer agents: cisplatin (a platinum compound that crosslinks DNA), doxorubicin (an anthracycline that intercalates DNA and inhibits topoisomerase II), folinic acid (a reduced folate that can enhance methotrexate effects), methotrexate (an antimetabolite that inhibits dihydrofolate reductase), and vinblastine (a vinca alkaloid that disrupts microtubule formation). This multi-drug approach targets cancer cells through different mechanisms to potentially improve efficacy.
02
Targets
DHFR (Dihydrofolate reductase)TOP2A (DNA topoisomerase II)DNATUBB (Tubulin (alpha and beta subunits))
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