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cisplatin + floxuridine
- Development stage
- Preclinical
- Lead developer
- Michigan State University
- Modality
- Small Molecules
- Administration
- Intra-arterial
01
Overview
Cisplatin + floxuridine is a combination chemotherapy regimen used primarily for the treatment of hepatic metastases from colorectal cancer. Cisplatin is a platinum-based antineoplastic agent that forms DNA crosslinks, inhibiting DNA synthesis and function, while floxuridine is an antimetabolite that interferes with DNA synthesis by inhibiting thymidylate synthase after conversion to fluorouracil or its active metabolites. The combination has been administered via hepatic arterial infusion for targeted delivery to liver tumors, resulting in improved response rates compared to systemic therapy alone[1][2][4].
- Other names
- CDDP + FUDRcisplatin and floxuridine
02
Targets
DNATS (Thymidylate synthase)
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