cisplatin + fluorouracil + gemcitabine + leucovorin

This is a multi-agent chemotherapy regimen composed of four drugs: - **Cisplatin** is a platinum-based compound that forms DNA crosslinks and inhibits DNA synthesis and function. - **Fluorouracil (5-FU)** is an antimetabolite that inhibits thymidylate synthase, disrupting DNA synthesis. - **Gemcitabine** is a nucleoside analog that incorporates into DNA during replication and causes chain termination. - **Leucovorin (folinic acid)** enhances the binding of 5-FU to thymidylate synthase, increasing its cytotoxicity. This combination has been explored in various advanced solid tumors such as pancreatic adenocarcinoma[1], biliary tract cancers[3][4][9], and metastatic renal cell carcinoma[2]. The rationale for combining these agents includes potential synergistic effects on tumor cell kill. However, the addition of multiple cytotoxics increases toxicity risk. This regimen does not have a unique brand name or code name; it is typically referred to by its component drugs.

Other names

cisplatin5-fluorouracilgemcitabineleucovorinCDDP + 5-FU + GEM + folinic acid