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A combination chemotherapy regimen consisting of cisplatin, fluorouracil, and lapatinib. Cisplatin is a platinum-based chemotherapy that forms DNA crosslinks disrupting cancer cell division. Fluorouracil (5-FU) is a pyrimidine analog that interferes with DNA synthesis by blocking thymidylate synthetase. Lapatinib is a dual inhibitor of HER2 and epidermal growth factor receptor (EGFR) tyrosine kinases.
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