Cisplatin + Ifosfamide + Mesna

The combination of cisplatin, ifosfamide, and mesna is a chemotherapy regimen used to treat various types of cancer. This combination therapy has been studied in clinical trials for several cancer types, including testicular cancer, ovarian cancer, lung cancer, and urothelial cancer.\n\nCisplatin is a platinum-based chemotherapy drug that works by forming DNA crosslinks, preventing cancer cells from dividing. Ifosfamide is a prodrug that requires metabolic activation by hepatic cytochrome P450 enzymes to exert its cytotoxic activity. Mesna is not a chemotherapy drug but a protective agent that prevents hemorrhagic cystitis, a potential side effect of ifosfamide treatment.