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cisplatin + lurbinectedin
- Development stage
- Phase 1
- Lead developer
- Jazz Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
A combination therapy consisting of cisplatin, a platinum-based chemotherapeutic agent, and lurbinectedin, a synthetic tetrahydroisoquinoline alkaloid that acts as a DNA minor groove binder. This combination has been investigated in clinical trials for the treatment of advanced solid tumors, including mesothelioma. The combination showed synergism in preclinical studies but faced challenges in clinical development due to toxicity limitations.
02
Targets
DNA
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