Drug intelligence / Profile preview

cistanche deserticola glycosides

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

**Cistanche deserticola glycosides** refers to a mixture of glycosides, predominantly phenylethanoid glycosides, extracted from the desert plant Cistanche deserticola, a notable traditional Chinese medicinal herb. The most abundant and biologically active glycosides in this extract are echinacoside and acteoside, along with others such as tubuloside A/B and isoacteoside. These compounds have demonstrated several pharmacological effects, including anti-inflammatory, antioxidant, and hepatoprotective actions. Cistanche deserticola glycosides have also shown neuroprotective and vasoprotective effects, improving outcomes in preclinical models of ischemic stroke and atherosclerosis, primarily via modulation of pathways such as Nrf2/Keap1 and PPARγ-LXRα-ABCA1. There are ongoing studies exploring their effect on neurological, hepatic, and cardiovascular diseases, but no approval for pharmaceutical indications outside of use as a traditional or dietary supplement in some countries[3][4][5][7].

Other names
total glycosides of cistanche deserticolaphenylethanoid glycosides of cistanche deserticola
02

Targets

KEAP1 (Kelch-like ECH-associated protein 1)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)NF-κBTLR4 (Toll-like receptor 4)ABCA1 (ATP-binding cassette transporter A1)NR1H3 (Liver X receptor beta)PPARG (Peroxisome proliferator-activated receptor gamma)

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