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Drug intelligence / Profile preview
cistanche tubulosa
- Development stage
- Preclinical
- Lead developer
- Fujian University of Traditional Chinese Medicine
- Administration
- Oral
01
Overview
*Cistanche tubulosa* is a medicinal herb widely utilized in Traditional Chinese Medicine (TCM), particularly for treating kidney deficiency and neurodegenerative disorders. The herb contains potent bioactive phenylethanoid glycosides, such as echinacoside and verbascoside, which have demonstrated significant neuroprotective and anti-apoptotic properties in models of Parkinson's disease (PD) and Alzheimer's disease. Its therapeutic mechanism involves the induction of endogenous neurotrophic factors, specifically glial cell-derived neurotrophic factor (GDNF), and the regulation of the nigrostriatal dopaminergic system. Research conducted by institutions like the Fujian University of Traditional Chinese Medicine suggests that nanopowder formulations of the herb can improve behavioral deficits and increase dopamine levels by protecting neurons from oxidative stress and toxin-induced damage.
- Other names
- C. tubulosaCistanche tubulosa nanopowderRou Cong Rong
02
Targets
BAX (Apoptosis regulator BAX)GDNF (Glial cell line-derived neurotrophic factor)GFRα1 (Glial cell line-derived neurotrophic factor receptor alpha 1)RET (Rearranged during transfection receptor tyrosine kinase)TH (Tyrosine hydroxylase)GFRA1 (Glial cell line-derived neurotrophic factor family receptor alpha 1)
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