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citicoline + omega-3 fatty acids + creatine
- Development stage
- Unknown
- Lead developer
- University of Utah Research Foundation
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This is a nutraceutical combination consisting of citicoline, creatine, and omega-3 fatty acids, developed by researchers at the University of Utah, including Dr. Deborah Yurgelun-Todd. The combination is designed to enhance cognitive function, specifically memory and attention, by targeting metabolic and bioenergetic pathways in the brain. Citicoline serves as a precursor for phospholipid synthesis and neurotransmitter production; creatine supports cellular energy homeostasis by maintaining ATP levels; and omega-3 fatty acids (typically EPA and DHA) are essential components of neuronal membranes with anti-inflammatory and neuroprotective properties. A clinical trial (NCT01502813) evaluated this specific formulation in healthy middle-aged women over a 28-day period, demonstrating potential benefits for neuropsychological measures of attention and memory.
- Other names
- Citicoline, Omega-3 Fatty Acids and Creatine
02
Targets
PPARA (Peroxisome proliferator-activated receptor alpha)PCYT1B (Choline-phosphate cytidylyltransferase beta)
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