Citodon

**Citodon** is a brand name for a fixed-dose combination tablet containing **paracetamol (acetaminophen) 500 mg** and **codeine phosphate 30 mg**, primarily used for short-term relief of moderate pain not adequately managed by paracetamol or NSAIDs alone. Paracetamol provides analgesic and antipyretic effects through central inhibition of prostaglandin synthesis and possibly other COX-independent mechanisms, while codeine, a prodrug metabolized to morphine by CYP2D6, acts as a weak mu-opioid receptor agonist to enhance pain relief. It is available as effervescent tablets in regions like Sweden, requires a prescription due to opioid content, and carries risks of side effects including constipation, nausea, drowsiness, hypotension, respiratory depression (especially in CYP2D6 ultra-rapid metabolizers), and addiction potential.

Brand names

Citodon

Other names

co-codamol