citrate buffer-Eyegate Pharmaceuticals, Inc.

Citrate buffer is a pharmaceutical-grade solution, typically formulated as a 100 mM sodium citrate buffer at pH 5.7, utilized by EyeGate Pharmaceuticals as a placebo control and vehicle in clinical trials. It is specifically used to evaluate the safety and tolerability of the EyeGate II Drug Delivery System, which employs transscleral iontophoresis technology. This delivery method uses a low-level electrical current to non-invasively drive charged drug substances across ocular tissues. In Phase 1 clinical studies involving healthy volunteers, the citrate buffer is delivered via iontophoresis to isolate and assess the safety profile of the delivery device itself, distinguishing the effects of the electrical current and administration method from those of active pharmaceutical ingredients like dexamethasone phosphate (EGP-437).

Other names

sodium citrate buffercitrate buffer solution