Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
Citrus IntegroPectin
- Development stage
- Preclinical
- Lead developer
- National Research Council of Italy
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Citrus IntegroPectin is a family of flavonoid-pectin bioconjugates obtained via hydrodynamic or acoustic cavitation of industrial citrus processing waste (such as orange, lemon, and grapefruit peels) in water. This green extraction process yields a low-methoxyl pectin backbone rich in rhamnogalacturonan-I (RG-I) 'hairy' regions, functionalized with adsorbed citrus flavonoids (such as hesperidin, naringin, and eriocitrin) and terpenes. Citrus IntegroPectin exhibits a broad range of biological activities, including antioxidant, anti-inflammatory, cardioprotective, neuroprotective, antimicrobial, and anticancer properties. In preclinical models, it has demonstrated cell-specific antitumor activity against lung and breast cancer cells by inducing apoptosis, reducing reactive oxygen species (ROS), upregulating miR-146, and downregulating interleukin-8 (IL-8).
- Other names
- IntegroPectincitrus IntegroPectin
02
Targets
LGALS3 (Galectin-3)IL8 (C-X-C Motif Chemokine Ligand 8)KATP channel (ATP-sensitive potassium channel)miR-146a (microRNA-146a)
Beyond the preview
Go deeper on Citrus IntegroPectin.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Citrus IntegroPectin.