Drug intelligence / Profile preview

citrus medica extract

Development stage
Preclinical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Citrus medica extract is a botanical extract derived from the leaves, bark, peel, or seeds of *Citrus medica* (commonly known as citron). It contains various bioactive phytochemicals, including flavonoids (such as apigenin, hesperetin, naringin, and quercetin), coumarins, and terpenoids. The extract has been investigated for its diverse pharmacological properties, including antioxidant, anti-inflammatory, antimicrobial, and cytotoxic/antitumor activities. Preclinical studies have demonstrated its potential in inhibiting the proliferation of breast and colorectal cancer cells, reducing blood glucose levels in diabetic models, and exhibiting neuroprotective and anti-depressive effects.

Other names
citron extractCitrus medica extractCitrus medica L. extract
02

Targets

ACE2 (Angiotensin-converting enzyme 2)STAT3 (Signal Transducer and Activator of Transcription 3)VEGFR2 (Vascular endothelial growth factor receptor 2)KEAP1 (Kelch-like ECH-associated protein 1)AMY (Pancreatic alpha-amylase)ERBB2 (Erb-b2 receptor tyrosine kinase 2)OATP1A2 (Solute carrier organic anion transporter family member 1A2)TP53 (Cellular Tumor Antigen p53 R175H)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)IL-6 (Interleukin 6)Sucrase-Isomaltase

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