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CKD-386
- Development stage
- Phase 4
- Lead developer
- Chong Kun Dang Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
CKD-386 is a fixed-dose triple combination therapy developed by Chong Kun Dang Pharmaceutical for the management of type 2 diabetes mellitus. It integrates three distinct mechanisms of action: lobeglitazone, a thiazolidinedione (TZD) that acts as a selective PPAR-gamma agonist to improve insulin sensitivity; sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor that enhances the incretin system; and metformin, a biguanide that reduces hepatic glucose production. The formulation is designed to provide a convenient single-pill regimen for patients requiring multiple glucose-lowering agents, potentially improving adherence and glycemic control. It was approved by the South Korean Ministry of Food and Drug Safety (MFDS) in 2023, becoming the first triple combination drug in Korea to include a thiazolidinedione.
- Brand names
- Duvie-S
- Other names
- Lobeglitazone + Metformin + SitagliptinDuvie S
02
Targets
PPARA (Peroxisome proliferator-activated receptor alpha)PPARG (Peroxisome proliferator-activated receptor gamma)DPP-4 (Dipeptidyl Peptidase-IV)CctA (Clostridium chauvoei toxin A)
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