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CKDB-501
- Development stage
- Phase 3
- Lead developer
- CKD Bio
- Modality
- Recombinant Proteins and Enzymes, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Intramuscular
01
Overview
**CKDB-501** is a novel serotype A botulinum toxin (BoNT/A) neuromodulator protein developed by CKD Bio, completely free from animal-derived components including human serum albumin, enhancing biocompatibility and reducing allergic reaction risks. It inhibits acetylcholine release at neuromuscular junctions by cleaving SNAP-25, leading to temporary muscle paralysis for aesthetic and potential therapeutic uses. Primary indication is moderate-to-severe glabellar lines, with Phase 3 non-inferiority demonstrated against onabotulinumtoxinA (Botox); preclinical/planned development for neuropsychiatric disorders like major depressive disorder and post-traumatic stress disorder via glabellar injections targeting amygdala activity.[1][3][6]
- Brand names
- Tyemvers
- Other names
- CKDB-501ACKDB501ACKDB 501A
02
Targets
SNAP25 (Synaptosome-associated protein 25)
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