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**ClōSYS Sensitive Fluoride Toothpaste** is a marketed human OTC anticaries dentifrice from Rowpar Pharmaceuticals. Its sole active drug ingredient is sodium fluoride 0.24%, equivalent to 0.13% w/v fluoride ion, which promotes remineralization of weakened tooth enamel and increases resistance to acid-mediated dental caries. The product is a sulfate-free, pH-balanced toothpaste containing stabilized chlorine dioxide as an inactive ingredient; it is labeled to aid prevention of dental decay and has received the American Dental Association Seal of Acceptance for helping prevent tooth decay when used as directed. ([dailymed.nlm.nih.gov](https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=5f87abb7-0e9d-6369-e053-2a91aa0a2411))
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