Drug intelligence / Profile preview

clarithromycin + rifampicin + ethambutol

Development stage
Unknown
Lead developer
Taisho Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

A three-drug antibiotic regimen consisting of clarithromycin, rifampicin, and ethambutol, primarily used for the treatment of Mycobacterium avium complex (MAC) infections. This combination is recommended by the American Thoracic Society and the Infectious Diseases Society of America as a standard treatment approach for MAC pulmonary disease and other MAC infections. The regimen works through multiple mechanisms to combat mycobacterial infections and is typically administered for extended periods.

Other names
REC
02

Targets

Bacterial 50S ribosomal subunitrpoB (DNA-directed RNA polymerase subunit beta)AftA (Arabinosyltransferase AftA)

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