clascoterone + benzoyl peroxide

Clascoterone + benzoyl peroxide is a topical combination therapy used in the treatment of acne vulgaris. Clascoterone is an androgen receptor inhibitor that acts locally in the skin to block dihydrotestosterone (DHT) from binding to androgen receptors in sebaceous glands and hair follicles, thereby reducing sebum production and inflammation. Benzoyl peroxide is an antimicrobial agent with keratolytic properties that reduces *Cutibacterium acnes* colonization and helps prevent follicular plugging. The combination targets multiple pathogenic factors of acne—hormonal stimulation of sebum production and bacterial proliferation/inflammation—making it a rational multimodal approach for moderate-to-severe acne vulgaris[3][4][6][8]. Clinical studies have shown that using these agents together can be effective and generally well tolerated, though concurrent application may increase local irritation such as redness or dryness[1][5].

Other names

cortexolone 17α-propionate