Drug intelligence / Profile preview

clascoterone + clindamycin + benzoyl peroxide

Development stage
Preclinical
Lead developer
Cassiopea
Modality
Small Molecules
Administration
Topical
01

Overview

This is a **topical combination treatment** for acne vulgaris that consists of three active components: **clascoterone**, **clindamycin**, and **benzoyl peroxide**. - **Clascoterone** is a topical androgen receptor antagonist that reduces sebum production and inhibits androgen-driven inflammation in the skin. - **Clindamycin** is a topical antibiotic that inhibits bacterial protein synthesis and reduces levels of *Cutibacterium acnes* (the bacteria implicated in acne). - **Benzoyl peroxide** is a topical antimicrobial and keratolytic agent that reduces bacterial load, helps prevent antibiotic resistance, and promotes exfoliation of the skin. This combination is designed to target multiple pathogenic pathways in acne: androgen-driven sebum production, bacterial colonization, inflammation, and follicular hyperkeratinization. No unique brand or code name is currently attributed to this specific three-drug combination; the constituents may be used together as separate products in practice[1][2][3].

Brand names
WinleviDuac
Other names
clascoterone + Duacclascoterone + benzoyl peroxide + clindamycin
02

Targets

GR (Glucocorticoid receptor)AR (Adrenergic receptors)Bacterial 50S ribosomal subunit

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