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CLB-3000
- Development stage
- Phase 1
- Lead developer
- ClearB Therapeutics
- Modality
- Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Intramuscular
01
Overview
**CLB-3000** is an investigational bivalent protein-subunit therapeutic vaccine from ClearB Therapeutics for chronic hepatitis B infection. It contains two proprietary engineered hepatitis B surface antigen variants, CLB-405 and CLB-505, designed to over-represent viral clearance-associated epitopes identified in individuals with functional cure, and is adjuvanted with Alhydrogel. The vaccine is intended to redirect or strengthen HBV-specific immune responses to promote functional cure, including reduction or clearance of hepatitis B surface antigen. CLB-3000 is being evaluated in an open-label Phase 1b study in adults with chronic hepatitis B receiving stable nucleoside or nucleotide analogue therapy. ([clearbtherapeutics.com](https://clearbtherapeutics.com/1313-2/))
- Other names
- CLB-405 + CLB-505 with Alhydrogel
02
Targets
HBsAg-specific BCR (HBsAg-specific B-cell receptor)Hepatitis B surface antigen-specific T-cell receptorHBsAg (Hepatitis B surface antigen)
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