clebopride

Clebopride is a small molecule dopamine antagonist with antiemetic and prokinetic properties, primarily used to treat functional gastrointestinal disorders such as gastroparesis, functional dyspepsia, gastroesophageal reflux disease (GERD), chronic gastritis, non-ulcer dyspepsia, and to prevent or treat nausea and vomiting—including that associated with chemotherapy[1][2][6][10]. Chemically related to metoclopramide, it acts by selectively blocking dopamine D2 receptors in the gastrointestinal tract and central nervous system. This antagonism enhances acetylcholine release via serotonin 5-HT4 receptor agonism in the GI tract, promoting smooth muscle contraction and improving gastric emptying and intestinal transit[8]. Its primary mechanism is focused on restoring normal gut motility. It is not typically used for other medical conditions outside of GI motility disorders.

Brand names

CleboprideCleboprida

Other names

clebopride malate4-Amino-N-(3-(diethylamino)propyl)-2-methoxybenzamide (chemical name)