Drug intelligence / Profile preview

clemastine fumarate + dexamethasone

Development stage
Unknown
Lead developer
Novartis
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Oral, Intravenous, Intramuscular, Topical
01

Overview

Clemastine fumarate + dexamethasone is a combination of two pharmaceutical agents used primarily for the treatment of allergic and inflammatory conditions. Clemastine fumarate is a first-generation antihistamine that acts as an antagonist at the histamine H1 receptor, thereby blocking the effects of endogenous histamine and providing relief from symptoms such as sneezing, runny nose, itching, and hives[2][6][8]. Dexamethasone is a synthetic corticosteroid with potent anti-inflammatory and immunosuppressive properties; it works by binding to glucocorticoid receptors to inhibit multiple inflammatory cytokines and suppress immune responses[4][5]. This combination may be used in clinical settings where both antihistaminic (for immediate allergy symptom relief) and anti-inflammatory (for reducing swelling or severe allergic reactions) actions are desired. The primary indications include severe allergies or skin conditions such as eczema[3].

Brand names
Dayhist + DecadronTavist + DecadronDayhist + DexPakTavist + DexPak
Other names
clemastine fumarate and dexamethasone
02

Targets

GR (Glucocorticoid receptor)HRH1 (Histamine H1 Receptor)

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