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Clematidis Radix is a traditional herbal medicine derived from the dried roots and rhizomes of *Clematis chinensis*, *Clematis mandshurica*, or *Clematis hexapetala*. It is widely used in East Asian traditional medicine, particularly in Korea and China, for its analgesic and anti-inflammatory properties. In the context of Korean medicine, it is often administered via pharmacopuncture—a technique involving the injection of herbal extracts into specific acupuncture points (such as ST36). Research indicates that Clematidis Radix exerts anti-osteoarthritic effects by inhibiting inflammatory mediators like cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), and various cytokines (IL-1β, IL-6, TNF-α), thereby protecting articular cartilage and synovial tissue from degradation.
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