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clentiazem
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Clentiazem is a benzothiazepine derivative and a calcium channel blocker, structurally related to diltiazem. Like diltiazem, clentiazem inhibits the influx of calcium ions through L-type calcium channels in cardiac and vascular smooth muscle, resulting in vasodilation and reduced myocardial workload. This mechanism underlies its potential antihypertensive and antianginal activity. Clentiazem is considered an analog of diltiazem with similar pharmacological effects, but it is not widely approved or marketed in major regions[2][10].
- Brand names
- clentiazem
- Other names
- clentiazemum96125-53-0DTXSID901028074DTXSID-901028074DTXSID 9010280748-chlorodiltiazemDTXCID901526911DTXCID-901526911DTXCID 901526911Clentiazem [INN]Clentiazemum [INN-Latin]UNII-40DK034DRCUNII40DK034DRCUNII 40DK034DRC(+)-cis-2-(4-Methoxyphenyl)-3-acetoxy-5-(2-(N,N-dimethylamino)ethyl)-8-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-oneClentiazem maleate
02
Targets
CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)
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