Drug intelligence / Profile preview

clerodendrum volubile ethyl acetate extract

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Clerodendrum volubile ethyl acetate extract is a plant-derived research compound obtained from the leaves of the *Clerodendrum volubile* plant, a species used in African ethnomedicine. The extract is rich in phenolic compounds, particularly protocatechuic acid, which is considered a key active ingredient. Preclinical research in type 2 diabetic rat models has shown that the extract possesses significant antidiabetic properties, characterized by a reduction in blood glucose levels, inhibition of alpha-glucosidase and glucose-6-phosphatase activities, and improvement in insulin secretion and pancreatic beta-cell function. It also demonstrates anti-inflammatory and antioxidant activities, including the inhibition of TNF-alpha and pancreatic lipase. While it is studied for metabolic and inflammatory conditions, it is not currently an approved pharmaceutical drug.

Other names
Clerodendrum volubile EtOAc extractC. volubile ethyl acetate extract
02

Targets

TNFA (Tumor necrosis factor alpha (soluble))CYP1A2 (Cytochrome P450 1A2)ACE (Angiotensin Converting Enzyme)Sucrase-IsomaltaseCYP3A4 (Cytochrome P450 3A4)

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