clevudine monophosphate

Clevudine monophosphate is the intracellular 5'-monophosphate metabolite of **clevudine**, an L-nucleoside pyrimidine analog antiviral developed for chronic hepatitis B. It is not generally the marketed drug itself, but rather an activated intermediate formed after the first phosphorylation step of clevudine and a designed payload delivered by the investigational prodrug ATI-2173. After further intracellular conversion to clevudine triphosphate, the active species inhibits **hepatitis B virus DNA polymerase reverse transcriptase**, suppressing HBV replication; published descriptions emphasize a non-chain-terminating, polymerase-inhibitory antiviral effect for the clevudine triphosphate metabolite. The entity is therefore best understood as a specific nucleotide metabolite and active moiety relevant to liver-targeted anti-HBV drug design rather than as a standalone commercial medicine.

Other names

clevudine 5'-monophosphateCLV-MP