Drug intelligence / Profile preview

clidinium

Development stage
Unknown
Lead developer
Roche
Modality
Small Molecules
Administration
Oral
01

Overview

Clidinium is a synthetic anticholinergic agent used primarily to treat gastrointestinal disorders such as peptic ulcer disease, irritable bowel syndrome (IBS), colicky abdominal pain, and diverticulitis. It acts by inhibiting the muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites, with a primary effect on M1 muscarinic receptors. This results in reduced gastric acid secretion and decreased gastrointestinal motility and spasms. Clidinium is often formulated in combination with chlordiazepoxide (a benzodiazepine) for enhanced therapeutic effect in conditions involving both anxiety and GI spasm[3][4][5].

Brand names
Quarzan
Other names
clidinium bromide
02

Targets

M1 (Muscarinic acetylcholine receptor M1)CHRM3 (M3)CHRM5 (M5)CHRM2 (M2)CHRM4 (M4)

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