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Climavita forte
- Development stage
- Unknown
- Lead developer
- Permamed
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Climavita forte is a Swissmedic-approved herbal medicinal product developed and marketed by Permamed for the relief of menopausal symptoms, including hot flashes, sweating, sleep disturbances, nervousness, and mood swings. The active ingredient is a dry extract of the Cimicifuga racemosa rhizome (black cohosh), with each film-coated tablet containing 13 mg of the extract. Climavita forte is characterized by its non-estrogenic, organ-selective mechanism of action, functioning as a selective estrogen receptor modulator (SERM) without exerting direct estrogenic effects on the uterus or breast tissue. Additionally, it modulates central nervous system pathways, acting as an agonist at the mu-opioid receptor, 5-HT7, 5-HT1A, and 5-HT1D serotonin receptors, and the dopamine D2 receptor, which collectively contribute to temperature regulation and emotional stability during menopause.
- Brand names
- ClimavitaClimavita forteClimavita neo
- Other names
- Cimicifuga racemosa rhizome dry extractblack cohosh extract
02
Targets
HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))HTR1D (5-hydroxytryptamine receptor 1D)HTR7 (5-hydroxytryptamine receptor 7)DRD2 (Dopamine D2 Receptor)ESR1 (ERα)ESR2 (ERβ)GABAA (Gamma-aminobutyric acid receptor)MOR (Mu opioid receptor)
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