Climbazole

Climbazole is a synthetic imidazole antifungal agent primarily used topically to treat human fungal skin infections such as dandruff, seborrhoeic dermatitis, and eczema. It is most commonly found in over-the-counter anti-dandruff shampoos, lotions, and conditioners. Climbazole exerts its therapeutic effect by inhibiting the synthesis of ergosterol in the fungal cell membrane through inhibition of the enzyme lanosterol 14α-demethylase. This disruption compromises membrane stability and leads to fungal cell death. Climbazole shows high efficacy against Malassezia species, which are implicated in dandruff pathogenesis. Its chemical structure is similar to other azole antifungals like ketoconazole and clotrimazole[1][6][7][8].

Other names

Baypival