clindamycin

Clindamycin is a semi-synthetic lincosamide antibiotic used to treat a variety of serious infections caused by susceptible microorganisms, including anaerobic bacteria and certain gram-positive cocci such as staphylococci and streptococci. It is also used topically for acne vulgaris. Clindamycin works by inhibiting bacterial protein synthesis through binding to the 23S RNA of the 50S subunit of the bacterial ribosome, thereby impeding ribosomal assembly and translation processes. This action results in bacteriostatic effects but can be bactericidal depending on concentration and organism. Clindamycin was developed by chemically modifying lincomycin, which was originally isolated from Streptomyces lincolnensis. It is indicated for infections such as lower respiratory tract infections (including pneumonia), skin and soft tissue infections, bone and joint infections (including osteomyelitis), intra-abdominal infections (such as peritonitis), gynecological infections (such as endometritis), septicemia, and severe acne[1][2][3][5][8].

Brand names

CleocinCleocin Pediatric

Other names

clindamycin phosphateClindaMax VaginalClindagelCleocin T