clindamycin + tretinoin

Clindamycin + tretinoin is a fixed-dose combination topical medication used to treat acne vulgaris, including severe nodular acne, in adults and children over 12 years old. Clindamycin is a lincosamide antibiotic that inhibits bacterial protein synthesis by binding to the 23S RNA of the 50S subunit of bacterial ribosomes, thereby reducing populations of *Propionibacterium acnes* (now *Cutibacterium acnes*), which are implicated in acne pathogenesis. Tretinoin is a retinoic acid derivative (vitamin A analog) that promotes skin cell turnover, reduces sebum production from oil glands, helps keep pores clear, and stimulates collagen synthesis for improved skin texture. The combination provides enhanced efficacy compared to either agent alone by targeting both inflammatory and non-inflammatory lesions while reducing the risk of antibiotic resistance[1][2][3][4][5].

Brand names

VeltinZiana

Other names

clindamycin and tretinoin topicaltretinoin/clindamycin topical