Drug intelligence / Profile preview

clindamycin phosphate + tretinoin + benzoyl peroxide

Development stage
Unknown
Lead developer
Valeant Pharmaceuticals
Modality
Small Molecules
Administration
Topical
01

Overview

This is a combination medication that contains three active ingredients working synergistically to treat acne vulgaris. Clindamycin phosphate (1.2%) is a topical antibiotic that kills acne-causing bacteria and reduces inflammation. Tretinoin (0.025%) is a retinoid that normalizes follicular hyperkeratinization, enhances skin cell renewal, and has anti-inflammatory properties. Benzoyl peroxide (typically 5-6%) provides keratolytic, antimicrobial, and anti-inflammatory effects. Together, these ingredients address three of the four major pathogenic factors in acne: they reduce bacterial colonization, normalize follicular hyperkeratinization, and decrease inflammation, though they do not reduce sebum production[1][6].

Brand names
ZIANATRIAZ
Other names
Clindamycin 1.2%-Tretinoin 0.025% Gel and Benzoyl Peroxide 4% WashCTGel + BPO WashClindamycin-Tretinoin Gel with Benzoyl Peroxide Wash
02

Targets

PTC (50S ribosomal peptidyl transferase center)RARA (Retinoic acid receptor alpha)

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